In this study, the children with NAFLD had a higher degree of obesity (BMI-z, mod-BMI-z and proportion of children with severe obesity) with higher levels of non-HDL-C and TG. This is consistent with published reports. In a retrospective cross-sectional analysis of 528 euthyroid children, Aypak et al found an association of higher levels of TSH and fT3 levels with obesity, and an association of increased level of dyslipidemia and higher systolic blood pressure with higher levels of TSH [31]. In a cohort of 49 prepubertal children with SH for a minimum of 2 years and age matched controls, Cerbone et al found higher cardiometabolic risk factors, measured in the form of waist to height ratio, atherogenic index (ratio of TC: HDL-C), TG: HDL-C ratio, homocysteine levels, and lower HDL-C levels [32]. These findings were replicated in a cohort of adolescents from the community-based Korea National Health and Nutrition Examination surveys [35]. Similar observations were made in a cohort of 22,147 children with Type 1 diabetes collected from multiple centers across Germany with or without the presence of autoantibodies [34]. Pacifico et al extended the observations of the association of metabolic findings with SH to NAFLD. Their study of 49 children with NAFLD and matched controls showed that in addition to the association with hypertriglyceridemia and insulin resistance, SH (TSH > 4.5 mIU/L) was associated with NAFLD, adjusting for age, gender, BMI and free T3/T4 levels [11]. In a separate study, higher insulin resistance, carotid intimal thickness and left ventricular mass were found in children and adolescents with SH and NAFLD compared to matched obese and lean controls [36].
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145: Hubens LE, Verloop WL, Joles JA, Blankestijn PJ, Voskuil M. Ischemia andreactive oxygen species in sympathetic hyperactivity states: a vicious cycle thatcan be interrupted by renal denervation? Curr Hypertens Rep. 2013Aug;15(4):313-20. doi: 10.1007/s11906-013-0367-y. Review. PubMed PMID: 23754326.
It must be evident even to the casual observer that society is undergoing a radical change in its fundamental conceptions. The World War and the Russian Revolution are the main causes of it. The war has unmasked the vicious character of capitalist competition and the murderous incompetency of governments to settle quarrels among nations, or rather among the ruling financial cliques. It is because the people are losing faith in the old methods that the Great Powers are now compelled to discuss limitation of armaments and even the outlawing of war. It is not so long ago that the very suggestion of such a possibility met with utmost scorn and ridicule.
I mention these instances to illustrate the fact that from time immemorial despots met their fate at the hands of outraged lovers of liberty. Such men were rebels against tyranny. They were generally patriots, Democrats or Republicans, occasionally Socialists or Anarchists. Their acts were cases of individual rebellion against wrong and injustice. Anarchism had nothing to do with it.
In the United States three Presidents were killed by individual acts. Lincoln was shot in 1865, by John Wilkes Booth, who was a Southern Democrat; Garfield, in 1881, by Charles Jules Guiteau, a Republican; and McKinley, in 1901, by Leon Czolgosz. Out of the three only one was an Anarchist.
As we have seen, acts of political violence have been committed not only by Anarchists, Socialists, and revolutionists of all kinds, but also by patriots and nationalists, by Democrats and Republicans, by suffragettes, by conservatives and reactionaries, by monarchists and royalists, and even by religionists and devout Christians.
So all through history, past and modern, the sense of right and justice has inspired man, individually and collectively, to deeds of self-sacrifice and devotion, and raised him far above the mean drabness of his every-day existence. It is tragic, of course, that this idealism expressed itself in acts of persecution, violence, and slaughter. It was the viciousness and self-seeking of king, priest, and master, ignorance and fanaticism which determined those forms. But the spirit that filled them was that of right and justice. All past experience proves that this spirit is ever alive and that it is a powerful and dominant factor in the whole scale of human life.
Second, the resistance of those who hold power. It makes no difference whether it is the church, the king, or kaiser, a democratic government or a dictatorship, a republic or an autocracy-those in authority will fight desperately to retain it as long as they can hope for the least chance of success. And the more aid they get from the slower-thinking majority the better the fight they can put up. Hence the fury of revolt and revolution.
They did, and that was one of the greatest mistakes they made. It was resented by the people as a wrong and it provoked irritation and discontent. The Bolsheviki had one kind of ration for the sailor, another of lower quality and quantity for the soldier, a third for the skilled worker, a fourth for the unskilled one; another ration again for the average citizen, and yet another for the bourgeois. The best rations were for the Bolsheviki, the members of the Party, and special rations for the Communist officials and commissars. At one time they had as many as fourteen different food rations. Your own common sense will tell you that it was all wrong. Was it fair to discriminate against people because they happened to be laborers, mechanics, or intellectuals rather than soldiers or sailors? Such methods were unjust and vicious: they immediately created material inequality and opened the door to misuse of position and opportunity, to speculation, graft, and swindle. They also stimulated counter-revolution, for those indifferent or unfriendly to the Revolution were embittered by the discrimination and therefore became an easy prey to counter-revolutionary influences.
Neurodegenerative eye diseases, such as glaucoma, cause irreversible vision loss in millions of patients worldwide, creating serious medical, economic and social issues. Like other mammalian central nervous system tracts, optic nerve intrinsically lacks the capacity for axonal growth and its surrounding environment is also non-permissive to regeneration. Any axonal damage also triggers a vicious cycle of retinal ganglion cell (RGC) death. Exploring methods that can enhance RGCs survival and promote axonal regeneration will not only enable vision restoration for millions of patients, but also shed light on the treatment of other neurodegenerative diseases. In this review article, we will go through three current approaches to cure neurodegenerative eye diseases, including cell based therapy, neuro-regeneration and neuro-rejuvenation. 2ff7e9595c
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